Tracking the origin and evolutionary dynamics of RNA editing in metazoans

Whole-genome DNA-seq and strand-specific RNA-seq on 18 species, including 14 metazoans and four unicellular eukaryotes closely related to metazoans. For each species, two to three (mostly three) specimens were sequenced to serve as biological replicates. For each specimen, we collected matching DNA-seq and RNA-seq data to control false positives resulted from genetic SNP during RNA-editing site identification.

本数据集包含18个物种的全基因组DNA测序（Whole-genome DNA-seq）与链特异性RNA测序（strand-specific RNA-seq）数据，其中涵盖14种后生动物（metazoans）以及4种与后生动物亲缘关系密切的单细胞真核生物（unicellular eukaryotes）。针对每个物种，我们采集2至3份（多数为3份）样本作为生物学重复（biological replicates）进行测序。对于每份样本，我们均配套收集了匹配的DNA测序与RNA测序数据，以在RNA编辑位点（RNA-editing site）的识别过程中，控制由遗传单核苷酸多态性（SNP）引发的假阳性结果。