Table_1_Association of childhood and adolescence obesity with incidence and mortality of adulthood cancers. A systematic review and meta-analysis.docx

BackgroundPrevalence and subsequent conditions of childhood and adolescent obesity are increasing. It has been seen that obesity in youth is associated with adulthood cancer. This systematic review and meta-analysis aimed to determine the pooled association of childhood obesity with cancers in adulthood.
MethodsIn this systematic review, international electronic databases such as Scopus, PubMed, Web of Science, and EMBASE were searched using relevant keywords until February 2022. All Cohort studies assessing the association of childhood and adolescent obesity (under 18 years old) with the incidence and mortality of all types of cancers were included. Two independent reviewers screened and carried out the quality assessment of included studies. Between-studies heterogeneity was assessed using the I squared and Cochran’s Q tests. Random/fixed-effect meta-analyses were used to pool the appropriate effect sizes (Hazard ratios (HR)).
ResultsOverall, 46 studies were found to be relevant and were included in this study. Based on the random-effects model meta-analysis, childhood obesity increased the hazard of cancer incidence and mortality in adulthood by 33% (HR: 1.33, 95%CI (1.25, 1.41)) and by 28% (HR: 1.28, 95%CI (1.13, 1.42)), respectively. In the subgroups meta-analysis, the HR of childhood obesity and adulthood cancer incidence mortality in women was higher than in men (HR=1.39, 95%CI (1.25, 1.53) vs HR= 1.20, 95%CI (1.07, 1.32)) and (HR= 1.40, 95%CI (1.10, 1.69) vs HR=1.20, 95%CI (1.04, 1.36)) respectively.
ConclusionThis study found that obesity in childhood and adolescence is associated with a significant increase in the incidence and mortality of cancers in adulthood. Prevention of childhood obesity, in addition to its short-term beneficial effects, can reduce the burden of cancer in adulthood. The data sets of this study are present in the Tables of the current manuscript. Moreover this study was registered online in PROSPERO (registration code: CRD42022331958).
Systemic review registrationhttps://www.crd.york.ac.uk/Prospero/, identifier CRD42022331958.

背景 儿童及青少年肥胖的患病率及其继发健康问题呈逐年上升趋势。现有研究证实，青少年肥胖与成年期癌症存在显著关联。本系统评价与荟萃分析旨在明确儿童肥胖与成年期癌症的合并关联效应。

方法 本项系统评价检索了Scopus、PubMed、Web of Science、EMBASE等国际电子数据库，检索策略采用相关关键词，检索时限截至2022年2月。纳入所有评估儿童及青少年（18岁以下）肥胖与各类癌症发病率、死亡率关联的队列研究。由2名独立评审员完成纳入研究的筛选与质量评价工作。采用I²检验与Cochran Q检验评估研究间异质性，并通过随机/固定效应模型荟萃分析合并效应量（风险比（Hazard ratios, HR））。

结果 最终共纳入46项相关研究。基于随机效应模型的荟萃分析结果显示，儿童肥胖可使成年期癌症发病风险升高33%（风险比=1.33，95%置信区间（95% Confidence Interval, 95%CI）[1.25, 1.41]），死亡风险升高28%（风险比=1.28，95%置信区间（95% Confidence Interval, 95%CI）[1.13, 1.42]）。亚组荟萃分析结果表明，女性儿童肥胖与成年期癌症发病、死亡的风险比均高于男性：发病风险比分别为1.39（95%CI[1.25, 1.53]）与1.20（95%CI[1.07, 1.32]）；死亡风险比分别为1.40（95%CI[1.10, 1.69]）与1.20（95%CI[1.04, 1.36]）。

结论 本研究证实，儿童及青少年肥胖与成年期癌症发病率、死亡率的显著升高存在关联。防控儿童肥胖，除可带来短期健康获益外，还可减轻成年期癌症的疾病负担。本研究数据集载于本文各表格中。此外，本研究已在PROSPERO平台完成在线注册（注册编号：CRD42022331958）。

系统评价注册 详见https://www.crd.york.ac.uk/Prospero/，标识符：CRD42022331958。