Methylation mValues

M-values of frontal methylation data from the RiMod-FTD resource (https://www.biorxiv.org/content/10.1101/2020.12.01.405894v4). <br> Data was processed as follows: <br> The Infinium MethylationEPIC BeadChip, which consists of 866,091 CpG locations, data was analyzed using the minfi R package. We removed all sites with a detection P-value above 0.01, on sex chromosomes and with single nucleotide polymorphisms (SNPs), leaving 810,290 loci for analysis. Data normalization was done using stratified quantile normalization. Sites with a standard deviation below 0.1 were considered uninformative and filtered out, leaving 170,595 sites that were used to perform a principal component analysis.本数据集包含RiMod-FTD资源（https://www.biorxiv.org/content/10.1101/2020.12.01.405894v4）的前额叶甲基化数据的M值（M-values）。 数据处理流程如下： 该数据集基于覆盖866091个CpG位点的Infinium甲基化EPIC微珠芯片（Infinium MethylationEPIC BeadChip）生成，采用minfi R包进行数据分析。 我们移除了所有检测P值大于0.01的位点、性染色体上的位点以及携带单核苷酸多态性（Single Nucleotide Polymorphisms, SNPs）的位点，最终保留810290个位点用于后续分析。 数据标准化采用分层分位数归一化（stratified quantile normalization）完成。 标准差低于0.1的位点被视为无信息位点并被过滤，最终得到170595个位点，用于开展主成分分析（Principal Component Analysis, PCA）。