Clinical data in subjects at all 3 time points (T0, T3, and T6) examined.

All 14 subjects are included in the analysis of parameters related to body weight and lipids. Decreases after RYGB were observed for BMI, weight, fat mass, fat free mass, resting energy expenditure and triglycerides. Leptin was also decreased significantly. While HDL-cholesterol decreased from T0 to T3, HDL-Cholesterol levels recovered by T6 and are confirmed by the lack of change in Apo-A1 levels. Total caloric intake decreased after RYGB; however, the relative proportion of lipid, carbohydrate, and protein consumed remained stable. When considering the 12 subjects not treated with insulin, glucose and insulin levels decreased post RYGB. Estimates for HOMA-IR and HOMA%B decreased while HOMA%S increased after surgery. Data presented as mean±standard error. * represents p<0.1 and ** represents p<0.05, assessed by a Friedman test.

本研究纳入全部14名受试者，以开展与体重及脂质代谢相关参数的分析。胃旁路术（Roux-en-Y Gastric Bypass，RYGB）术后，受试者的身体质量指数（Body Mass Index，BMI）、体重、脂肪量、去脂体重、静息能量消耗及甘油三酯水平均出现下降，瘦素（Leptin）水平亦显著降低。尽管高密度脂蛋白胆固醇（HDL-cholesterol）水平在T0至T3期间有所下降，但在T6时已恢复至基线水平，该结果可通过载脂蛋白A1（Apolipoprotein A1，Apo-A1）水平无变化得到佐证。总热量摄入在RYGB术后有所减少，但受试者膳食中脂质、碳水化合物与蛋白质的相对占比维持稳定。针对未接受胰岛素治疗的12名受试者，其血糖及胰岛素水平在RYGB术后均出现下降。术后，胰岛素抵抗指数（Homeostatic Model Assessment for Insulin Resistance，HOMA-IR）与β细胞功能指数（Homeostatic Model Assessment of β-cell Function，HOMA%B）的估算值均有所降低，而胰岛素敏感性指数（Homeostatic Model Assessment of Insulin Sensitivity，HOMA%S）的估算值则出现升高。所有数据均以均值±标准误的形式呈现。其中*表示P<0.1，**表示P<0.05，统计检验采用Friedman检验。