Additional file 10: Table S5. of Genome-wide transcriptome profiling reveals functional networks involving the Plasmodium falciparum drug resistance transporters PfCRT and PfMDR1

Assessment of a possible time shift in gene expression between parasite lines. We examined the data to assess whether some genes displayed a shifted timing of expression between parasite strains. By comparing peaks of expression for each gene in each pairwise comparison, we determined the number of genes whose peak of expression was shifted of a determined number of hours. 0 corresponds to a shift of less than 1 h, one corresponds to a shift of at least 1 h but less than two hours, etc. Therefore, two genes cannot be more than 24 h apart of each other in either direction. We observed that more than 70 % of all genes peaked within the same 8-hour window in the pfmdr1 dataset (Table S5A) while about 80 % of the genes peaked within the same 5-hour window in the pfcrt dataset (Table S5B). (XLSX 44 kb)

寄生虫株系间基因表达时序偏移的评估。我们对数据集展开分析，以探究部分基因在不同寄生虫株系间是否存在表达时序偏移的情况。通过在每一组两两比对中分析每个基因的表达峰值，我们统计了表达峰值偏移时长为特定小时数的基因数量。其中0代表偏移时长不足1小时，1代表偏移时长≥1小时且<2小时，以此类推。因此，任意两个基因的表达峰值偏移方向的时长差距均不超过24小时。我们观察到，在pfmdr1数据集（表S5A）中，超过70%的基因的表达峰值集中在同一8小时窗口内；而在pfcrt数据集（表S5B）中，约80%的基因表达峰值集中在同一5小时窗口内。（XLSX格式，44 KB）