Dinuclear Copper(I) Complexes as Precatalysts in Ullmann and Goldberg Coupling Reactions

The use of structurally well-characterized copper(I) species as precatalysts in C−N and C−S bond forming reactions is described. Two new dinuclear Cu(I) complexes containing two isomeric ligands of bis(7-azaindolyl)methane have been synthesized and fully characterized by NMR and X-ray diffraction studies. Both copper(I) species exhibit a 1:1 Cu/L ratio and have been used as precatalysts in the N-arylation of 2-pyrrolidinone and S-arylation of thiols with aryl iodides. The complexes efficiently catalyze these cross-coupling reactions, affording high yields of products under mild conditions.

本研究报道了将结构表征清晰的铜(I)物种用作C-N键与C-S键形成反应预催化剂的工作。合成了两种带有双(7-氮杂吲哚基)甲烷异构配体的新型双核铜(I)配合物，并通过核磁共振波谱法（NMR）与X射线衍射分析对其完成了全面表征。两种铜(I)物种均呈现1:1的铜与配体摩尔比，且被用作2-吡咯烷酮的N-芳基化反应以及芳基碘化物与硫醇的S-芳基化反应的预催化剂。该类配合物可高效催化上述交叉偶联反应，在温和反应条件下即可获得较高产率的目标产物。