Thromboprophylaxis and maternal-fetal outcomes of women with serum markers for hereditary thrombophilia and previous obstetric complications

Abstract Objectives: to evaluate the maternalfetal outcomes of thromboprophylaxis with enoxa parin based on scoring system in women with serum markers for hereditary thrombophilia and previous obstetric complications. Methods: a retrospective study was undertaken based on data collected from clinical records. We included 54 pregnant women with serum markers for hereditary thrombophilia undergoing therapeutic intervention with enoxaparin in the period from November 2009 to December 2013. The initial dose of low molecular weight heparin was guided by a scoring system. The maternalfetal outcomes of previous pregnancies and, subsequently, the treatment were compared using the chisquare (χ2) test with the Yates correction and Fisher's Exact Test; p摘要 研究目的：评估基于评分系统的依诺肝素（enoxaparin）血栓预防方案，在存在遗传性血栓形成倾向血清标志物且既往有产科并发症的孕妇中的母胎结局。 研究方法：本研究为回顾性研究，数据来源于临床病历记录。本研究纳入2009年11月至2013年12月期间，54名存在遗传性血栓形成倾向血清标志物且接受依诺肝素干预的孕妇。低分子肝素（low molecular weight heparin）的初始给药剂量以评分系统为指导依据。采用经耶茨校正的卡方（χ²）检验与费希尔精确检验，对比既往妊娠与本次治疗后的母胎结局；P