USP10 stabilizes BAZ1A to drive tumor stemness via an epigenetic mechanism in head and neck squamous cell carcinoma

Aberrant epigenetic remodeling events occurred in head and neck squamous cell carcinoma (HNSCC) contribute to tumor stemness and chemotherapy resistance, yet little is known. This study conducted the epigenetic sequencing to uncover the role of USP10-BAZ1A axis in driving HNSCC progression.

头颈部鳞状细胞癌（HNSCC）中发生的异常表观遗传重塑（epigenetic remodeling）事件可促进肿瘤干细胞性（tumor stemness）与化疗耐药（chemotherapy resistance），然而目前对此的认知仍较为有限。本研究通过表观基因组测序（epigenetic sequencing），旨在揭示USP10-BAZ1A轴（USP10-BAZ1A axis）在驱动头颈部鳞状细胞癌进展中的作用。