Dataset related to article "The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients"

This set of data is related to article "The antibody response to SARS-CoV-2 infection persists over at least 8 months in symptomatic patients" Abstract The factors involved in the persistence of antibodies to SARS-CoV-2 are unknown. We evaluated the antibody response to SARS-CoV-2 in personnel from 10 healthcare facilities and its association with individuals’ characteristics and COVID-19 symptoms in an observational study. We enrolled 4735 subjects (corresponding to 80% of all personnel) over a period of 5 months when the spreading of the virus was drastically reduced. For each participant, we determined the rate of antibody increase or decrease over time in relation to 93 features analyzed in univariate and multivariate analyses through a machine learning approach. In individuals positive for IgG ( ≥ 12 AU/mL) at the beginning of th study, we found an increase [p= 0.0002] in antibody response in symptomatic subjects, particularly with anosmia/dysgeusia (OR 2.75, 95% CI 1.753 – 4.301), in a multivariate logistic regression analysis. This may be linked to the persistence of SARS-CoV-2 in the olfactory bulb.本数据集关联于学术论文《症状患者体内严重急性呼吸综合征冠状病毒2（SARS-CoV-2）抗体应答至少持续8个月》。 **摘要**：目前尚不明确与SARS-CoV-2抗体持续存在相关的调控因素。本研究为一项观察性研究，纳入10所医疗机构的工作人员，对其体内针对SARS-CoV-2的抗体应答情况进行评估，并分析该应答与个体特征及新型冠状病毒肺炎（COVID-19）症状的关联。在病毒传播得到大幅抑制的5个月周期内，我们共纳入4735名受试者，占全体工作人员的80%。针对每名受试者，我们通过机器学习方法开展单变量与多变量分析，对93项特征进行关联分析，以此确定其抗体水平随时间推移的升降速率。在研究初始时免疫球蛋白G（IgG）抗体阳性（≥12 AU/mL）的受试者中，经多变量逻辑回归分析显示，有症状人群的抗体应答水平显著升高（p=0.0002），尤以嗅觉缺失/味觉障碍人群最为显著（比值比（Odds Ratio, OR）=2.75，95%置信区间（Confidence Interval, CI）：1.753~4.301）。该现象或与SARS-CoV-2在嗅球内的持续存留相关。