SSEA-4 labels a subset of poor prognosis-associated osteosarcoma-initiating cells that respond to differentiation induction

Osteosarcoma is thought of arising from the malignant transformation of osteogenic progenitors. The stage-specific embryonic antigen-4 (SSEA-4) labels a subset of TICs specially present in the high-risk subgroup. SSEA-4+ AND SSEA-4-

骨肉瘤被认为起源于成骨祖细胞的恶性转化。阶段特异性胚胎抗原4（stage-specific embryonic antigen-4，SSEA-4）可标记一类特异性存在于高风险亚组中的肿瘤起始细胞（Tumor-Initiating Cells，TICs）亚群。SSEA-4阳性与SSEA-4阴性。