Dataset for "Dissociable Roles of the mPFC-to-VTA pathway in the control od Impulsive action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats"

This dataset corresponds to the study "Dissociable Roles of the mPFC-to-VTA Pathway in the Control of Impulsive Action and Risk-Related Decision-Making in Roman High- and Low-Avoidance Rats". In this study, we used Positron Emission Tomography with [18F]-Fluorodeoxyglucose to evaluate brain metabolic activity in Roman High- (RHA) and Low-avoidance (RLA) rats, which exhibit innate differences in impulsivity. Notably, we used a viral-based intersectional chemogenetic strategy to isolate the role of the mPFC-to-VTA pathway in controlling impulsive behaviors. We selectively activated the mPFC-to-VTA pathway in RHA rats and inhibited it in RLA rats, assessing the effects on impulsive action and RDM in the rat gambling task. Our results showed that RHA rats displayed higher impulsive action, less optimal decision-making, and lower cortical activity than RLA rats at baseline. Chemogenetic activation of the mPFC-to-VTA pathway reduced impulsive action in RHA rats, whereas chemogenetic inhibition had the opposite effect in RLA rats. However, these manipulations did not affect RDM. Our findings suggest a dissociable role of the mPFC-to-VTA pathway in impulsive action and RDM, highlighting its potential as a target for investigating impulsivity-related disorders. Contributions for usage of this data in publications: If you publish any work using these data, please cite this repository and the associated publication.本数据集对应研究《罗马高回避（RHA）与低回避（RLA）大鼠的内侧前额叶皮层-腹侧被盖区（mPFC-VTA）通路在动作冲动控制与风险相关决策中的分离性功能》。本研究采用[18F]-氟代脱氧葡萄糖（[18F]-Fluorodeoxyglucose）正电子发射断层扫描技术，评估在冲动性层面存在先天差异的罗马高回避（RHA）与罗马低回避（RLA）大鼠的脑代谢活动。值得注意的是，本研究运用基于病毒的交叉型化学遗传学策略，以明确mPFC-VTA通路在动作冲动行为调控中的独立作用。我们选择性激活RHA大鼠的mPFC-VTA通路，并抑制RLA大鼠的该通路，随后通过大鼠赌博任务评估上述操作对动作冲动与风险相关决策（Risk-Related Decision-Making, RDM）的影响。 研究结果显示，基线状态下，RHA大鼠相较于RLA大鼠，表现出更高的动作冲动性、更劣的最优决策能力以及更低的皮层代谢活性。对mPFC-VTA通路实施化学遗传学激活可降低RHA大鼠的动作冲动性，而化学遗传学抑制则在RLA大鼠中产生相反效应。但此类操作并未对风险相关决策造成影响。本研究结果表明，mPFC-VTA通路在动作冲动与风险相关决策中发挥分离性功能，提示该通路或可作为冲动性相关疾病研究的潜在靶点。 数据集使用引用要求：若您使用本数据集开展研究并发表相关成果，请同时引用本数据集仓库及本关联研究论文。