VEGF concentration and receptor densities for the tissue (human vastus lateralis).

The conversion of receptor densities to tissue: see table 2. Endothelial cell surface area = 1000 µm2. Conversions are as follow: VEGF concentration: 6.2 107 (pmol/cm3 tissue)/M (here, M = moles/liter interstitial fluid available to VEGF); VEGF binding sites in the ECM and BMs: 6.2 107 (pmol/cm3 tissue)/M (ECM fluid accessible to VEGF), 5.7 104 (pmol/cm3 tissue)/M (EBM fluid accessible to VEGF), 3.1 105 (pmol/cm3 tissue)/M (MBM fluid accessible to VEGF). For example, M(EBM) = moles/liter endothelial basement membrane. Conversions from pg/mg protein are based on 155 mg protein/g of tissue and 45 kDa VEGF, 210 kDa VEGFR1, 240 kDa VEGFR2 [18].

受体密度向组织的换算参见表2。内皮细胞表面积为1000 µm²。换算关系如下：血管内皮生长因子（Vascular Endothelial Growth Factor, VEGF）浓度：6.2×10⁷ (pmol/cm³组织)/M（此处M指可与VEGF结合的组织间隙液的摩尔浓度，单位为mol/L）；细胞外基质（Extracellular Matrix, ECM）与基底膜（Basement Membranes, BMs）中的VEGF结合位点：6.2×10⁷ (pmol/cm³组织)/M（可与VEGF结合的ECM液）、5.7×10⁴ (pmol/cm³组织)/M（可与VEGF结合的内皮基底膜液）、3.1×10⁵ (pmol/cm³组织)/M（可与VEGF结合的微血管基底膜液）。例如，M(EBM)指内皮基底膜的摩尔浓度（单位为mol/L）。由pg/mg蛋白进行的换算基于以下参数：每克组织含155 mg蛋白，VEGF分子量为45 kDa，VEGF受体1（Vascular Endothelial Growth Factor Receptor 1, VEGFR1）为210 kDa，VEGF受体2（Vascular Endothelial Growth Factor Receptor 2, VEGFR2）为240 kDa[18]。