Large-Scale Synthesis of All Stereoisomers of a 2,3-Unsaturated C-Glycoside Scaffold

All stereoisomers of a highly functionalized 2,3-unsaturated C-glycoside can be accessed in 10−100 g quantities from readily available starting materials and reagents in 3−7 steps. These chiral scaffolds contain three stereogenic centers along with orthogonally protected functional groups for downstream reactivity.可通过易得的起始原料与试剂，经3至7步反应，以10克至100克的批量制备一种高度官能团化2,3-不饱和C-糖苷（C-glycoside）的全部立体异构体。该类手性骨架包含三个手性中心，同时带有正交保护的官能团，可用于后续反应。