PVA Hydrogel Lens Characterization

The ocular diseases rising from vascular endothelial growth factors (VEGF) is rising on an alarming rate. Mostly the complex retinal disorders are resulted from overexpression of VEGF. Common ocular complications such as age related macular edema (AMD) (over 196 million), diabetic retinopathy (DR) (over 103.12 million) and retinal vein occlusion can result to permanent vision loss if not treated early. Early treatment of such complications is inhibiting the VEGF signaling cascade via anti-VEGF therapy. Common drug administration involves topical eye drop which limits the percentage of bioavailability. Similarly, panretinal photocoagulation or intra/intervitreal administration through injections can lead to retinal scars/injury. PVA-based Hydrogel Ocular Lens characterization data is appended here. This can also be used as a Platform to construct Smart Lens. The Data contains Transmittance, Drug Delivery, biotoxicity, SEM, Swelling, Surface Roughness, and encapsulation, time relevance for the Lens. 

由血管内皮生长因子（vascular endothelial growth factor, VEGF）引发的眼部疾病正以惊人的速度增长。绝大多数复杂视网膜疾病均由VEGF过度表达所引发。常见眼部并发症包括年龄相关性黄斑水肿（AMD，患病人数超1.96亿）、糖尿病视网膜病变（DR，患病人数超1.0312亿）以及视网膜静脉阻塞，若未及时接受治疗，均可导致永久性视力丧失。针对此类并发症的早期治疗可通过抗VEGF疗法阻断VEGF信号传导级联反应。常见给药方式为局部滴眼，但该方式的生物利用度有限。类似地，全视网膜光凝术或经注射的眼内/玻璃体内给药方式可能会引发视网膜瘢痕或损伤。
本数据集附有基于聚乙烯醇（polyvinyl alcohol, PVA）的水凝胶眼部透镜表征数据，该体系还可作为构建智能透镜的平台。该数据集涵盖该透镜的透光率、药物递送性能、生物毒性、扫描电子显微镜（scanning electron microscope, SEM）表征结果、溶胀性能、表面粗糙度、包封率以及时间相关性相关数据。