Supplementary Material for: Four Actionable Bottlenecks and Potential Solutions to Translating Psychiatric Genetics Research: An Expert Review

Background: Psychiatric genetics has had limited success in translational efforts. A thorough understanding of the present state of translation in this field will be useful in the facilitation and assessment of future translational progress. Purpose: A narrative literature review was conducted. Combinations of 3 groups of terms were searched in EBSCOhost, Google Scholar, and PubMed. The review occurred in multiple steps, including abstract collection, inclusion/exclusion criteria review, coding, and analysis of included papers. Results: One hundred and fourteen articles were analyzed for the narrative review. Across those, 4 bottlenecks were noted that, if addressed, may provide insights and help improve and increase translation in the field of psychiatric genetics. These 4 bottlenecks are emphasizing linear translational frameworks, relying on molecular genomic findings, prioritizing certain psychiatric disorders, and publishing more reviews than experiments. Conclusions: These entwined bottlenecks are examined with one another. Awareness of these bottlenecks can inform stakeholders who work to translate and/or utilize psychiatric genetic information. Potential solutions include utilizing nonlinear translational frameworks as well as a wider array of psychiatric genetic information (e.g., family history and gene-environment interplay) in this area of research, expanding which psychiatric disorders are considered for translation, and when possible, conducting original research. Researchers are urged to consider how their research is translational in the context of the frameworks, genetic information, and psychiatric disorders discussed in this review. At a broader level, these efforts should be supported with translational efforts in funding and policy shifts.

研究背景：精神遗传学领域的转化研究成果较为有限。深入明晰该领域当前的转化研究现状，将有助于推动并评估未来的转化研究进展。
研究目的：本研究采用叙述性文献综述的研究方法。在EBSCOhost、Google Scholar及PubMed数据库中，检索了3组检索词的组合查询。综述流程包含多个环节：摘要收集、纳入/排除标准审核、编码以及对纳入文献的分析。
研究结果：本叙述性综述共分析了114篇文献。经梳理后发现了4项瓶颈问题，若能针对性解决这些问题，或可为精神遗传学领域的转化研究提供新思路，并助力提升该领域的转化效率与规模。这4项瓶颈分别为：过度强调线性转化框架、过度依赖分子基因组学研究结果、优先聚焦特定精神疾病、综述类文献发表量远超实验类研究。
研究结论：上述瓶颈问题彼此相互交织、彼此关联。明晰这些瓶颈，可为从事精神遗传学转化研究或相关信息应用工作的利益相关方提供参考依据。潜在的解决方案包括：在该研究领域采用非线性转化框架、拓展精神遗传学相关信息的研究范畴（例如家族史与基因-环境交互作用）、扩大可纳入转化研究的精神疾病范围，以及在条件允许的情况下开展原创性实验研究。研究人员应结合本综述所探讨的转化框架、遗传学信息与精神疾病范畴，考量自身研究的转化价值。从更宏观的视角而言，相关研究工作应获得资助与政策调整层面的转化研究配套支持。