SARS-CoV-2 mutational trajectories dataset

This dataset contains mutation frequency data derived from in vitro evolution experiments of the SARS-CoV-2 spike receptor-binding domain (RBD), conducted under low-stringency (LSS) and high-stringency (HSS) selection pressures. The data capture position-specific mutation distributions and frequencies across multiple rounds of selection and across several RBD variants. These experiments were designed to assess how laboratory-driven evolution parallels the natural evolution of SARS-CoV-2, particularly in the context of ACE2 receptor binding — the critical first step in viral infection.本数据集包含源自针对新型冠状病毒（SARS-CoV-2）刺突蛋白受体结合域（RBD）的体外进化实验的突变频率数据，相关实验在低严格度（LSS）与高严格度（HSS）两种选择压力下开展。该数据集记录了多轮筛选过程以及多种RBD变体中的位点特异性突变分布与突变频率。此类实验旨在评估实验室诱导的进化与新冠病毒自然进化的相似性，尤其聚焦于作为病毒感染关键起始步骤的ACE2（血管紧张素转换酶2）受体结合场景。