Fc mutant (K392D/K409D/D399K)

Fc mutant (K392D/K409D/D399K) Descriptor: Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Ye, S, Xu, T, Yu, J, Wang, X, Xu, T, Jin, Q, Duan, J, Wu, J, Wu, H. Deposit date: 2017-08-07 Release date: 2017-09-13 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.653 Å) Cite: A rational approach to enhancing antibody Fc homodimer formation for robust production of antibody mixture in a single cell line J. Biol. Chem., 292, 2017

Fc突变体（K392D/K409D/D399K）样本描述：免疫球蛋白γ-1重链，其糖基化修饰为beta-D-半乳糖吡喃糖-(1→4)-2-乙酰氨基-2-脱氧-alpha-D-葡萄糖吡喃糖-(1→2)-alpha-D-甘露吡喃糖-(1→6)-[2-乙酰氨基-2-脱氧-beta-D-葡萄糖吡喃糖-(1→2)-beta-D-甘露吡喃糖-(1→3)]beta-D-甘露吡喃糖-(1→4)-2-乙酰氨基-2-脱氧-beta-D-葡萄糖吡喃糖-(1→4)-[beta-L-岩藻吡喃糖-(1→6)]2-乙酰氨基-2-脱氧-beta-D-葡萄糖吡喃糖，以及beta-D-半乳糖吡喃糖-(1→4)-2-乙酰氨基-2-脱氧-alpha-D-葡萄糖吡喃糖-(1→2)-alpha-D-甘露吡喃糖-(1→6)-[beta-D-甘露吡喃糖-(1→3)]beta-D-甘露吡喃糖-(1→4)-2-乙酰氨基-2-脱氧-beta-D-葡萄糖吡喃糖-(1→4)-2-乙酰氨基-2-脱氧-beta-D-葡萄糖吡喃糖。作者：Ye S、Xu T、Yu J、Wang X、Xu T、Jin Q、Duan J、Wu J、Wu H。提交日期：2017年8月7日；发布日期：2017年9月13日；最后修改日期：2024年11月13日。检测方法：X射线衍射（分辨率2.653 Å）。引用文献：《增强抗体Fc同源二聚体形成以在单个细胞系中稳定制备抗体混合物的理性策略》，《生物化学杂志》（*J. Biol. Chem.*），第292卷，2017年。