LncRNA CHROME regulates the interferon response to viral challenge [RNA-Seq]. LncRNA CHROME regulates the interferon response to viral challenge [RNA-Seq]

Long non-coding RNAs (lncRNAs) are important regulators of the immune response. Here we identify a novel function for the primate-specific lncRNA, CHROME. We established that CHROME is most highly transcribed in human macrophages treated with influenza virus and/or polyIC. Overall design: We used three replicate samples of THP cells that were treated with gapmer targeting CHROME and subsequently treated these cells with polyIC.

长链非编码RNA（long non-coding RNAs，lncRNAs）是免疫应答的关键调控因子。本研究鉴定出灵长类特异性长链非编码RNA CHROME的全新功能。研究证实，CHROME在经流感病毒和/或聚肌胞苷酸（polyIC）处理的人巨噬细胞中呈现最高转录水平。实验设计：本研究采用经靶向CHROME的间隙型反义寡核苷酸（gapmer）处理后的THP细胞的三份重复样本，并对上述细胞后续施加聚肌胞苷酸（polyIC）处理。