Cav3.2-/- Mouse #256 CA1 EEG recording

A Ca_v3.2-/- mouse (internal #256) was implanted with an intrahippocampal electrode for electrohippocampal CA1 EEG recordings. The differential electrode of the TA10ETA-F20 transmitter (Data Science International, DSI, USA, technical specifications: weight 3.9 g, volume 1.9 cc, input voltage range ± 2.5 mV, channel bandwidth (B) 1–200 Hz, nominal sampling rate (f) 1000 Hz (f = 5 B), temperature operating range 34–41 °C) was positioned at the following stereotaxic coordinates: (+)-lead, caudal − 2 mm, lateral of bregma 1.5 mm (right hemisphere), and dorsoventral (depth) 1.5 mm. The epidural reference electrode was positioned on the surface of the cerebellar cortex at the following stereotaxic coordinates: (−)-lead, bregma − 6 mm and lateral of bregma 1 mm (right<br> hemisphere). The deep tungsten electrodes (FHC, USA) are encapsuled with epoxylite with an<br> impedance of 50–100 kΩ (measured at 1000 Hz) and a shank diameter of 250 μm. For further details on the Ca_v3.2 mouse model, animal experimentation approval, anaesthesia, transmitter insertion, stereotaxic electrode implantation, postoperative pain management and recovery, please refer to Arshaad MI et al., 2021. EEG data were exported to NeuroScore 3.2.9306-1 (Data Sciences International, DSI, USA). As the NeuroScore file format does not allow free access to the data, we have exported the raw EEG data as asci.-files, so that they can easily be imported in secondary analysis software. Importantly, the exported EEG data represent raw EEG data. No filtering, no artefact detection and/or artefact removal have been carried out. Thus, it is the users responsibility to adequately pretreat the data before further processing and analysis. As described in Arshaad MI et al. (2021), filtering, artefact detection and removal was carried out using NeuroScore before further analysis. The EEG data are presented here as a zip-folder for size reasons. Four EEG recordings are exported: R1 (a first 24h long-term EEG recording 10 days post transmitter implantation), R2 (a second 24h long-term recording 17 days post transmitter implantation), U1 (a 6h EEG recording following the first urethane injection (800 mg/kg i.p.) at day 18 post transmitter implantation), U2 (a 6h EEG recording after a second urethane injection (800 mg/kg i.p.) at day 25 post transmitter implantation). In addition, relative activity values are exported for all four recordings. For details on the recording procedure, please refer to Arshaad MI et al. (2021).本实验使用1只内部编号为256的Ca_v3.2基因敲除（Ca_v3.2^-/-）小鼠，为其植入海马内电极以开展海马CA1区脑电图（Electroencephalogram, EEG）记录。本研究采用TA10ETA-F20型发射器（美国数据科学国际公司（Data Science International，简称DSI），技术参数：重量3.9g，体积1.9cc，输入电压范围±2.5mV，通道带宽（B）1~200Hz，标称采样率（f）1000Hz（f=5B），工作温度范围34~41℃）的差分电极，其立体定位坐标如下：正向导（+）：尾侧-2mm，距前囟（bregma）外侧1.5mm（右侧大脑半球），背腹侧（深度）1.5mm。硬膜外参考电极置于小脑皮层表面，立体定位坐标如下：负向导（-）：前囟-6mm，距前囟外侧1mm（右侧大脑半球）。本研究使用的深插入式钨电极（FHC，美国）采用epoxylite环氧包封漆封装，阻抗为50~100kΩ（1000Hz下测得），电极针杆直径为250μm。关于Ca_v3.2小鼠模型、动物实验伦理审批、麻醉、发射器植入、立体定位电极植入、术后镇痛与恢复的详细信息，请参阅Arshaad MI等人2021年的研究。脑电图数据被导出至NeuroScore 3.2.9306-1软件（美国数据科学国际公司，DSI）。由于NeuroScore的文件格式无法直接开放数据访问，本数据集将原始脑电图数据导出为asci.-格式文件，以便用户可轻松将其导入至二次分析软件中。重要提示：本数据集导出的脑电图数据均为原始数据，未经过滤波处理、伪迹检测或伪迹移除操作。因此，用户需在开展后续处理与分析前对数据进行充分的预处理。如Arshaad MI等人（2021）所述，在进行后续分析前，研究团队曾使用NeuroScore软件完成滤波、伪迹检测与移除操作。出于文件大小考虑，本数据集的脑电图数据以zip压缩包形式提供。本数据集共导出4组脑电图记录：R1为发射器植入后第10天采集的首次24小时长时程脑电图记录；R2为发射器植入后第17天采集的第二次24小时长时程脑电图记录；U1为发射器植入后第18天首次腹腔注射氨基甲酸乙酯（intraperitoneal, i.p.，800mg/kg）后采集的6小时脑电图记录；U2为发射器植入后第25天第二次腹腔注射氨基甲酸乙酯（intraperitoneal, i.p.，800mg/kg）后采集的6小时脑电图记录。此外，本数据集还导出了4组记录对应的相对活动度数值。关于记录流程的详细信息，请参阅Arshaad MI等人（2021）的研究。