Local control of human papillomavirus infection after anal condylomata acuminata eradication

OBJECTIVE: To verify whether the eradication of anal condylomata acuminata was effective for local control of HPV infection using anal colposcopy and anal brush cytology.METHODS: We evaluated 147 patients treated for anal margin and/or anal canal condyloma, with 108 HIV-positive and 39 HIV-negative individuals. The average age for males was 40 years for HIV-positive and 27.5 for HIV-negative. In females, the mean age was 37.5 years for HIV-positive and 31.5 for HIV-negative.RESULTS: Twenty-four patients (16.3%) had normal cytology and anal colposcopy, 16 (10.9%) normal cytology and altered anal colposcopy, 52 (35.4%) normal anal colposcopy and altered cytology, and 55 (37.4%) had altered cytology and anal colposcopy.CONCLUSION: the eradication of clinical lesions failed to locally control HPV infection.

研究目的：采用肛门阴道镜检查与肛门刷片细胞学检查，验证肛门尖锐湿疣（anal condylomata acuminata）根除治疗对人乳头瘤病毒（HPV，Human Papillomavirus）感染的局部控制效果。
研究方法：本研究纳入147例接受肛周和/或肛管尖锐湿疣治疗的患者，其中人类免疫缺陷病毒（HIV，Human Immunodeficiency Virus）阳性者108例，HIV阴性者39例。男性患者中，HIV阳性者平均年龄为40岁，HIV阴性者为27.5岁；女性患者中，HIV阳性者平均年龄为37.5岁，HIV阴性者为31.5岁。
研究结果：24例患者（16.3%）细胞学检查与肛门阴道镜检查结果均正常；16例（10.9%）细胞学检查正常但肛门阴道镜检查结果异常；52例（35.4%）肛门阴道镜检查正常但细胞学检查结果异常；另有55例（37.4%）细胞学检查与肛门阴道镜检查结果均异常。
研究结论：临床病灶根除治疗未能实现人乳头瘤病毒感染的局部控制。