Table1_The impact of alcohol consumption on the relationship between depression and chronic diarrhea: a cross-sectional study analysis on NHANES (2005-2010).docx

BackgroundAlcohol consumption, depression, and chronic diarrhea are all public health issues of concern, with irreversible consequences for individual health and significant economic burdens on health care systems. Previous studies have shown that depression increases the risk of developing chronic diarrhea, but few studies have explored whether alcohol consumption has an effect on the relationship between depression and chronic diarrhea.
ObjectiveTo explore the effect of alcohol consumption on the relationship between depression and chronic diarrhea.
Methods12,538 adults (≥20 years) in NHANES from 2005-2010 were analyzed. Participants were stratified according to drinking status, and differences between the risk of depression and chronic diarrhea among participants who drank alcohol or not were assessed using multiple regression analysis and likelihood ratio tests.
ResultsIn this cross sectional, after adding possible confounders, the prevalence of depression with chronic diarrhea was higher in the drinking population than in the non-drinking population (OR,2.34, 95%CI:1.84-2.98 and 1.26, 95%CI:0.85-1.86), with a likelihood ratio test of P=0.024.
ConclusionOur findings suggest that there is a significant association between depression and chronic diarrhea and that alcohol consumption may increase the correlation between depression and chronic diarrhea. However, these findings require further prospective studies to provide more evidence.

背景：饮酒、抑郁与慢性腹泻均为备受关注的公共卫生问题，其不仅会对个体健康造成不可逆的损害，还会给医疗保健系统带来沉重的经济负担。既往研究表明，抑郁可增加慢性腹泻的发病风险，但目前鲜有研究探讨饮酒对抑郁与慢性腹泻之间关联的影响。
研究目的：探讨饮酒对抑郁与慢性腹泻二者之间关联的影响。
研究方法：分析2005-2010年美国国家健康与营养调查（National Health and Nutrition Examination Survey, NHANES）中12538名年龄≥20岁的成年受试者。根据饮酒状态对受试者进行分层，采用多元回归分析与似然比检验，评估饮酒者与非饮酒者之间抑郁与慢性腹泻的患病风险差异。
研究结果：本项横断面研究中，在调整潜在混杂因素后，饮酒人群中伴慢性腹泻的抑郁患病率高于非饮酒人群（比值比（Odds Ratio, OR）=2.34，95%置信区间（Confidence Interval, CI）：1.84~2.98；非饮酒人群OR=1.26，95%CI：0.85~1.86），似然比检验结果显示P=0.024。
研究结论：本研究结果显示，抑郁与慢性腹泻之间存在显著关联，且饮酒可能会增强二者之间的相关性。不过上述研究结论尚需进一步的前瞻性研究提供更多证据支持。