Redox-sensitive High-mobility group box-1 isoforms contribute to liver fibrosis progression and resolution in mice. Redox-sensitive High-mobility group box-1 isoforms contribute to liver fibrosis progression and resolution in mice

To study role of different HMGB1 isoforms in liver fibrosis and resolution Overall design: RNA sequencing was performed in total liver at peak fibrosis and resoluand, rHSC was treated with different HMGB1 isoforms for 6 hours

为探究不同高迁移率族蛋白B1（High Mobility Group Box 1, HMGB1）亚型在肝纤维化及其消退过程中的作用，整体实验设计如下：在纤维化峰值期与消退期的全肝组织中开展RNA测序；将大鼠肝星状细胞（rHSC）用不同HMGB1亚型处理6小时。