Palladium-Catalyzed Double Alkylation of 3‑Aryl-2-fluoroallyl Esters with Malonate Nucleophiles through the Carbon–Fluorine Bond Cleavage

The alkylation of (Z)-3-aryl-2-fluoroallyl acetate with the malonate anion by the [Pd­(C3H5)­(cod)]­BF4/2,2′-bpy catalyst proceeds through the carbon–fluorine bond cleavage, and 2 equiv of the malonate nucleophile was introduced to the allyl substrate.以[Pd(C3H5)(cod)]BF4/2,2'-联吡啶(2,2′-bpy)为催化剂，丙二酸阴离子与(Z)-3-芳基-2-氟乙酸烯丙酯的烷基化反应经由碳氟键断裂路径进行，且需向烯丙基底物中引入2当量的丙二酸亲核试剂。