Human GRK2 in complex with Gbetagamma subunits and CCG224062
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Human GRK2 in complex with Gbetagamma subunits and CCG224062 Descriptor: (4~{S})-4-[4-fluoranyl-3-(isoquinolin-1-ylmethylcarbamoyl)phenyl]-~{N}-(1~{H}-indazol-5-yl)-6-methyl-2-oxidanylidene-3,4-dihydro-1~{H}-pyrimidine-5-carboxamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... Authors: Cato, M.C, Tesmer, J.J.G. Deposit date: 2016-01-05 Release date: 2016-05-11 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (3.15 Å) Cite: Structure-Based Design, Synthesis, and Biological Evaluation of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors. J.Med.Chem., 59, 2016
结合Gβγ亚基与CCG224062的人源GRK2（Human GRK2）
配体描述：(4S)-4-[4-氟-3-(异喹啉-1-基甲基氨基甲酰基)苯基]-N-(1H-吲唑-5-基)-6-甲基-2-氧代-3,4-二氢-1H-嘧啶-5-甲酰胺；β肾上腺素能受体激酶1（Beta-adrenergic receptor kinase 1）；鸟苷酸结合蛋白G(I)/G(S)/G(O)亚基γ-2（Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2）……
作者：Cato, M.C.、Tesmer, J.J.G.
沉积日期：2016-01-05
发布日期：2016-05-11
最后修改日期：2024-03-06
实验方法：X射线衍射（3.15埃）
引用文献：《高选择性强效G蛋白偶联受体激酶2抑制剂的基于结构设计、合成及生物学评价》，J.Med.Chem.，59卷，2016年
创建时间：
2016-01-05
