Data and analysis scripts for: Lung adenocarcinoma promotion by air pollutants

Code for "Lung adenocarcinoma promotion by air pollutants" manuscript egfrm_lc_incidence Epidemiological analyses of EGFRm lung cancer incidence and PM2.5 levels in England (NHS England), South Korea and Taiwan. ukbb Epidemiological analyses of lung cancer incidence and PM2.5 levels in England, using the UKBB data set. mouse_RNA_seq Analysis of RNA-seq data derived from lung tumour tissue of pollution-exposed mice. mouse_WGS Analysis of WGS data derived from lung tumour tissue of pollution-exposed mice. normal_lung Analysis of ddPCR for EGFRm from normal lung tissue from the TRACERx and PEACE cohorts. Analysis of Duplex-seq data from normal lung tissue from the PEACE and BDRE cohorts.本内容为《空气污染促进肺腺癌》（Lung adenocarcinoma promotion by air pollutants）学术论文的配套代码，涵盖以下多项数据分析任务： 1. egfrm_lc_incidence：基于英国国民保健署（NHS England）、韩国及中国台湾地区的相关数据，开展表皮生长因子受体突变型（EGFRm）肺癌发病率与PM2.5水平的流行病学分析； 2. ukbb：依托英国生物样本库（UKBB）数据集，针对英格兰地区开展肺癌发病率与PM2.5水平的流行病学分析； 3. mouse_RNA_seq：对污染暴露小鼠的肺肿瘤组织RNA测序（RNA-seq）数据进行分析； 4. mouse_WGS：对污染暴露小鼠的肺肿瘤组织全基因组测序（WGS）数据进行分析； 5. normal_lung：针对TRACERx与PEACE队列的正常肺组织，开展EGFRm液滴数字PCR（ddPCR）分析；同时针对PEACE与BDRE队列的正常肺组织，开展双链测序（Duplex-seq）数据分析。