The open field assay is influenced by room temperature and by drugs that affect core body temperature

The data demonstrate how changes in core body temperature influence locomotor activity. Open field was performed at 25C and 4C in C57BL/6 mice and TRPM8-/- mice. Mice were also treated with diazepam and the TRPM8 antagonist, M8-B, to demonstrate these changes in locomotor activity are affected by changes in core body temperature. Data also show how different buildings on the same campus can be maintained at different temperatures and show how these can vary based on the season.

本数据集阐明了核心体温（core body temperature）的变化对动物运动活动（locomotor activity）的调控机制。研究人员分别于25℃与4℃环境下，对C57BL/6小鼠及TRPM8基因敲除小鼠（TRPM8-/- mice）开展旷场实验（Open field）。此外，通过对小鼠给予地西泮（diazepam）与TRPM8拮抗剂（TRPM8 antagonist）M8-B处理，验证了上述运动活动变化确实受核心体温变化的调控。本数据集同时展示了同一校园内不同楼宇可维持差异化温度，且此类温度设置会随季节发生动态波动。