Comparative analysis of bile acid composition and metabolism in the liver of Bufo gargarizans aquatic larvae and terrestrial adults

Bile acids are crucial for lipid metabolism and their composition and metabolism differ among species. However, there have been no data on the differences in the composition and metabolism of bile acids between aquatic larvae and terrestrial adults of amphibians. This study explored the differences in composition and metabolism of bile acid between Bufo gargarizans larvae and adults. The present study will provide valuable insights into understanding metabolic disorders and exploring novel bile acid-based therapeutics.

胆汁酸（bile acids）对脂质代谢至关重要，且不同物种的胆汁酸组成与代谢模式存在差异。然而，目前尚无关于两栖动物水生幼体与陆生成体之间胆汁酸组成及代谢差异的相关数据。本研究针对中华蟾蜍（Bufo gargarizans）幼体与成体的胆汁酸组成与代谢差异展开探究。本研究将为理解代谢紊乱机制以及探索基于胆汁酸的新型治疗手段提供有价值的参考视角。