Total Synthesis of (±)-7-<i>epi</i>-Nemorosone

A concise total synthesis of (±)-7-epi-nemorosone is reported. Our synthetic approach establishes a viable route to polycyclic polyprenylated acylphloroglucinol natural products (PPAP’s) bearing a C-7 endo prenyl side chain. Key steps include retro-aldol-vinyl cerium addition to a hydroxy adamantane core scaffold and palladium-mediated deoxygenation.本文报道了(±)-7-表-尼莫洛松((±)-7-epi-nemorosone)的简洁全合成。本合成策略为带有C-7内型异戊烯侧链的多环多异戊烯基酰基间苯三酚类天然产物（polycyclic polyprenylated acylphloroglucinols, PPAPs）提供了一条可行的合成路径。关键反应步骤包括以羟基金刚烷核心骨架为底物的逆羟醛-乙烯基铈加成反应，以及钯介导的脱氧反应。