single-nucleus sequencing of PrL tissue from mice

we tested whether MG-derived VDBP is biased toward specific neuronal subtypes during CUMS to induce depression. We performed single-nucleus sequencing of PrL tissue from VDBP-overexpressing mice (AAV-VDBP) and control mice (AAV-mCherry).

我们旨在探究慢性不可预见性温和应激（CUMS）过程中，小胶质细胞衍生的维生素D结合蛋白（VDBP）是否会偏向特定神经元亚型，进而诱发抑郁。我们对过表达VDBP的小鼠（AAV-VDBP）与对照小鼠（AAV-mCherry）的prelimbic皮层（PrL）组织开展了单细胞核测序。