Host genetic variation guides hepacivirus clearance, chronicity, and liver fibrosis in mice

The dataset describes the host transcriptional response in WT and Collaborative Cross lines infected with Norway rat hepacivirus. We infected WT C57BL/6 mice as well as Collaborative Cross strains CC046, CC071 and CC080 with 1E+05 genome equivelents of Norway rat hepacivirus. Bulk RNAseq was performed on total RNA from the liver at 7 days post infection.

本数据集旨在描述野生型（Wild Type，WT）及协作杂交（Collaborative Cross，CC）品系感染挪威大鼠肝炎病毒（Norway rat hepacivirus）后的宿主转录应答特征。本研究以1×10^5基因组当量的挪威大鼠肝炎病毒，分别感染野生型C57BL/6小鼠以及协作杂交品系CC046、CC071与CC080；于感染后7天采集肝脏组织总RNA，进行批量RNA测序（Bulk RNA-seq）分析。