Supplementary Files.

<b>Supplementary Datasheet 1. </b>SNPs numbers of GM and GM-associated metabolites for four outcomes.<b>Supplementary Datasheet 2.</b> Causal effects of all GMs and GM-associated metabolites on four outcomes.<b>Supplementary Datasheet 3. </b>Sensitivity and causal direction analysis results including all GMs.<b>Supplementary Datasheet 4. </b>Sensitivity and causal direction analysis results including all GM-associated metabolites.<b>Supplementary Datasheet 5. </b>SNPs used for inflammatory factor mediation analysis.<b>Supplementary Datasheet 6. </b>SNPs used for immune cell mediation analysis.<b>Supplementary Datasheet 7. </b>SNPs used for plasma protein mediation analysis.<b>Supplementary Datasheet 8. </b>SNPs information supplementary of significant causal associations between GMs or associated metabolites and outcomes.<b>Supplementary Datasheet 9. </b>Basic information of clinical patients included in this research.<b>Supplementary Table 1.</b> Numbers of GM types at different taxonomic levels and corresponding Bonferroni-corrected significance thresholds.<b>Supplementary Figure 1. </b>Statistical analysis of clinical patient basic information. <b>(A-D).</b> Statistical analysis of IVDD patient basic information<b>.(E-H).</b> Statistical analysis of CDD patient basic information.

<b>补充数据表1</b>：四种结局对应的肠道菌群（Gut Microbiota，GM）及其相关代谢物的单核苷酸多态性（Single Nucleotide Polymorphism，SNPs）数量。
<b>补充数据表2</b>：所有肠道菌群及其相关代谢物对四种结局的因果效应。
<b>补充数据表3</b>：纳入所有肠道菌群的敏感性分析与因果方向分析结果。
<b>补充数据表4</b>：纳入所有肠道菌群相关代谢物的敏感性分析与因果方向分析结果。
<b>补充数据表5</b>：用于炎症因子中介分析的单核苷酸多态性。
<b>补充数据表6</b>：用于免疫细胞中介分析的单核苷酸多态性。
<b>补充数据表7</b>：用于血浆蛋白中介分析的单核苷酸多态性。
<b>补充数据表8</b>：肠道菌群或其相关代谢物与结局间显著因果关联的单核苷酸多态性补充信息。
<b>补充数据表9</b>：本研究纳入的临床患者基本信息。
<b>补充表1</b>：不同分类学水平的肠道菌群型别数量及对应邦费罗尼校正显著性阈值。
<b>补充图1</b>：临床患者基本信息统计分析。<b>(A-D)</b>：椎间盘退变（Intervertebral Disc Degeneration，IVDD）患者基本信息统计分析。<b>(E-H)</b>：颈椎间盘疾病（Cervical Disc Disease，CDD）患者基本信息统计分析。