Expression data from sevoflurane anesthesia treated rat

Long noncoding RNAs (lncRNAs) play important roles in brain function modulation and neurodegenerative diseases. However, whether lncRNA regulations are involved in the mechanisms of perioperative neurocognitive disorders (PNCD), especially in anesthesia related brain dysfunction, remains unknown. We explored the expression and regulation pattern profiles of lncRNAs in the hippocampus of aged rats after sevoflurane anesthesia with microarrays. We focused on lncRNA and gene expression patterns in the hippocampus of aged rats after sevoflurane anesthesia. And we established functional annotation of differentially expressed (DE)-lncRNAs and their potential target genes, as well as lncRNA-mRNA co-expression network to reveal the role of lncRNAs in sevoflurane anesthesia related brain function modulation.

长链非编码RNA（Long noncoding RNAs, lncRNAs）在脑功能调控与神经退行性疾病中发挥重要作用。然而，长链非编码RNA的调控是否参与围手术期神经认知障碍（perioperative neurocognitive disorders, PNCD）的发病机制，尤其是麻醉相关脑功能异常的病理过程，目前仍不明确。本研究通过基因微阵列技术，分析了七氟烷麻醉后老年大鼠海马组织中长链非编码RNA的表达及调控模式谱。研究聚焦于七氟烷麻醉后老年大鼠海马组织内的长链非编码RNA与基因表达模式，对差异表达（differentially expressed, DE）长链非编码RNA及其潜在靶基因进行功能注释，并构建长链非编码RNA-mRNA共表达网络，以揭示长链非编码RNA在七氟烷麻醉相关脑功能调控中的作用。