DNA methylome profiling (Bisulfite Sequencing) of human iPSC-derived midbrain astrocytes in ATP13A2 c.1306deficiency models

This Zenodo deposit contains a publicly available description of the Dataset: Title: "DNA methylome profiling (Bisulfite Sequencing) of human iPSC-derived midbrain astrocytes in ATP13A2 c.1306deficiency models". Description: This dataset provides base-resolution DNA methylation profiles generated via Whole-Genome Bisulfite Sequencing (WGBS) of human iPSC-derived midbrain astrocytes. The study contrasts the methylome of ATP13A2 c.1306 mutants with Wild Type (WT) controls. The objective was to evaluate overall DNA methylation levels and regional epigenetic modifications associated with the genotype. This dataset is designed to be integrated with companion RNA-seq and ATAC-seq data to provide a multi-omic characterization of the model. This dataset is made available to researchers via the ASAP CRN Cloud: cloud.parkinsonsroadmap.org. Instructions for how to request access can be found in the User Manual. This research was funded by the Aligning Science Across Parkinson's Collaborative Research Network (ASAP CRN), through the Michael J. Fox Foundation for Parkinson's Research (MJFF). This Zenodo deposit was created by the ASAP CRN Cloud staff on behalf of the dataset authors. It provides a citable reference for a CRN Cloud Dataset本Zenodo存档包含某公开数据集的说明文档： 标题：《ATP13A2 c.1306缺陷模型中人诱导多能干细胞（induced pluripotent stem cell，iPSC）来源的中脑星形胶质细胞的DNA甲基化组谱分析（亚硫酸氢盐测序，Bisulfite Sequencing）》 数据集说明：本数据集通过全基因组亚硫酸氢盐测序（Whole-Genome Bisulfite Sequencing，WGBS）获取了人诱导多能干细胞（iPSC）来源的中脑星形胶质细胞的单碱基分辨率DNA甲基化谱。本研究将ATP13A2 c.1306突变体的甲基化组与野生型（Wild Type，WT）对照样本进行对比，旨在评估与该基因型相关的整体DNA甲基化水平及区域表观遗传修饰变化。本数据集可与配套的RNA测序（RNA-seq）与转座酶可及性测序（ATAC-seq）数据整合，以实现该模型的多组学特征解析。 本数据集通过帕金森病研究对齐协作网络（Aligning Science Across Parkinson's Collaborative Research Network，ASAP CRN）云平台向研究人员开放，访问地址为cloud.parkinsonsroadmap.org。权限申请的操作说明可查阅用户手册。 本研究由ASAP CRN通过迈克尔·J·福克斯帕金森研究基金会（Michael J. Fox Foundation for Parkinson's Research，MJFF）资助完成。 本Zenodo存档由ASAP CRN云平台工作人员代表数据集作者创建，可为CRN云平台数据集提供可引用的参考文献。