Table 1_Positive association between serum lactate dehydrogenase levels and blood pressure: evidence from NHANES 2015–2016.docx

BackgroundSerum lactate dehydrogenase (sLDH) is an enzyme implicated in tissue injury and inflammatory responses. Despite its established role in these pathophysiological processes, the association between sLDH and blood pressure remains underexplored. The present findings suggest that sLDH could emerge as a valuable biomarker for blood pressure regulation and may hold significant promise in the management of hypertension.
MethodsOur investigation utilized data from the National Health and Nutrition Examination Survey (NHANES) 2015–2016, comprising 3,469 participants after excluding those under the age of 20, individuals on antihypertensive therapies, and cases with incomplete data. sLDH levels were categorized into tertiles, while blood pressure measurements were conducted under standardized protocols. To elucidate the relationship between sLDH levels and blood pressure, multivariate regression analyses and smooth curve fitting techniques were employed, adjusting for 17 covariates, including age, sex, and body mass index.
ResultssLDH corresponds with both systolic blood pressure (SBP) and diastolic blood pressure (DBP). The adjusted smooth curve fitting diagram demonstrates a linear positive connection between sLDH and SBP, with an increment of 0.053 mmHg (95% CI: 0.032, 0.074; p < 0.001) in SBP for every 1 U/L increment in LDH concentrations. The connection between sLDH and DBP is non-linear. sLDH concentrations below 123 U/L have a linear positive connection with DBP, increasing 0.079 mmHg (95% CI: 0.042, 0.115, p < 0.001). When sLDH concentrations exceed 123 U/L, there is not a substantial connection with DBP (P = 0.574).
ConclusionOur study demonstrates a linear positive correlation between sLDH and SBP. A non-linear association was observed between sLDH and DBP, with a positive relationship for sLDH levels below 123 U/L. These findings underscore the potential of sLDH as a biomarker for blood pressure regulation.

研究背景：血清乳酸脱氢酶（serum lactate dehydrogenase, sLDH）是一种参与组织损伤与炎症反应的酶类。尽管其在上述病理生理过程中的作用已得到证实，但血清乳酸脱氢酶与血压之间的关联仍未得到充分探索。本研究结果显示，血清乳酸脱氢酶有望成为血压调控的潜在有效生物标志物，并在高血压管理领域展现出重要应用前景。
研究方法：本研究使用2015-2016年全国健康与营养检查调查（National Health and Nutrition Examination Survey, NHANES）的数据，经排除20岁以下人群、接受降压治疗者及数据不全者后，最终纳入3469名研究对象。将血清乳酸脱氢酶水平分为三分位组，血压测量严格遵循标准化流程。为阐明血清乳酸脱氢酶水平与血压的关联，本研究采用多因素回归分析和平滑曲线拟合方法，校正了包括年龄、性别、体质量指数在内的17项协变量。
研究结果：血清乳酸脱氢酶水平与收缩压（systolic blood pressure, SBP）及舒张压（diastolic blood pressure, DBP）均存在关联。校正后的平滑曲线拟合图显示，血清乳酸脱氢酶与收缩压呈线性正相关：血清乳酸脱氢酶浓度每升高1 U/L，收缩压升高0.053 mmHg（95%CI：0.032~0.074；P<0.001）。血清乳酸脱氢酶与舒张压的关联则呈非线性特征：当血清乳酸脱氢酶浓度低于123 U/L时，其与舒张压呈线性正相关，浓度每升高1 U/L，舒张压升高0.079 mmHg（95%CI：0.042~0.115；P<0.001）；当血清乳酸脱氢酶浓度超过123 U/L时，二者未观察到显著关联（P=0.574）。
研究结论：本研究证实，血清乳酸脱氢酶与收缩压呈线性正相关；其与舒张压则呈非线性关联，当血清乳酸脱氢酶水平低于123 U/L时二者呈正相关。上述结果凸显了血清乳酸脱氢酶作为血压调控生物标志物的潜在应用价值。