MMP inhibitory potencies of compounds 4a-e and 10a-d.

IC50: half maximal inhibitory concentration. Values expressed in nM are presented as mean ± SD of three independent experiments in duplicate. Selectivity was calculated as the ratio of IC50 values; MMP1 IC50 for each respective compound was divided by the respective MMP2 or MMP9 IC50. The higher the selectivity value, the greater the selectivity towards either MMP2 or MMP9 relative to MMP1 for each respective compound.

IC50即半最大抑制浓度（half maximal inhibitory concentration），本数据集中原以纳摩尔（nM）为单位的数值，均以三次独立重复实验（每份样品设置双复孔）的平均值±标准差（SD）呈现。选择性通过IC50比值计算：将各化合物的基质金属蛋白酶1（MMP1）IC50值，分别除以对应的基质金属蛋白酶2（MMP2）或基质金属蛋白酶9（MMP9）IC50值。该选择性数值越高，则表明对应化合物相较于MMP1，对MMP2或MMP9的选择性越强。