Gene expression profile at the single cell level of human breast tissues of BRCA1/BRCA2 mutation carriers. Gene expression profile at the single cell level of human breast tissues of BRCA1/BRCA2 mutation carriers

Goal of this study is to develop the single cell map of breast tissues of women who carry germline mutations in BRCA1 or BRCA2 genes. Towards this goal, we performed single cell RNA sequencing (sc-RNAseq) of cells isolated from cryopreserved tissues. Overall design: Gene expression profile at the single cell level of human breast tissues of BRCA1/BRCA2 mutation carriers

本研究旨在构建携带BRCA1或BRCA2生殖系突变的女性乳腺组织单细胞图谱。为此，我们对从冷冻保存组织中分离得到的细胞进行了单细胞RNA测序（single cell RNA sequencing，scRNA-seq）。整体实验设计：本数据集包含BRCA1/BRCA2突变携带者的人类乳腺组织单细胞水平基因表达谱。