Selection of strongly correlating genes.

Human genes with orthologues first seen in either C. elegans, D. melanogaster or T. rubripes and then a total of at least six orthologues (providing four degrees of freedom) were processed. Human genes from sets of orthologues that had correlation values greater than a boundary value, set as the correlation value with a probability of p< 0.05 in a two-tailed t-test, were selected. This identified 100 genes first seen in C. elegans, 50 genes first seen in D. melanogaster and 48 genes first seen in T. rubripes.

本研究对满足以下条件的人类基因开展处理流程：其直系同源基因（orthologue）首次发现于秀丽隐杆线虫（C. elegans）、黑腹果蝇（D. melanogaster）或红鳍东方鲀（T. rubripes），且该基因对应的直系同源基因总数至少为6个（对应4个自由度）。随后，从上述同源基因集合中筛选相关值高于临界值的人类基因，该临界值被设定为双侧t检验中显著性概率p<0.05所对应的相关数值。经上述步骤筛选后，共获得首次发现于秀丽隐杆线虫的人类基因100个、首次发现于黑腹果蝇的人类基因50个，以及首次发现于红鳍东方鲀的人类基因48个。