Nanopore sequencing of Canine Atopic Dermatitis cases and controls

Canine atopic dermatitis (AD) is an inflammatory skin disease showing clinical similarities to human AD. Several dog breeds are at increased risk for developing this disease. To identify genetic risk factors for canine AD, we applied a Bayesian model adapted for mapping complex traits (BayesR) and a cross-population extended haplotype test (XP-EHH) to search for disease-associated selective sweeps in four dog breeds at risk for AD. Two cases and two controls were whole genome sequenced with Nanopore to further investigate the risk haplotypes.

犬特应性皮炎（Canine atopic dermatitis, AD）是一类与人类特应性皮炎临床特征相似的炎症性皮肤病。多个犬品种罹患该病的风险显著升高。为探明犬特应性皮炎的遗传风险因素，本研究采用适配复杂性状定位的贝叶斯模型（BayesR）与跨群体扩展单倍型检验（XP-EHH），在4个易感犬品种中搜寻与疾病相关的选择性清除信号。同时，我们对2例病例样本与2例对照样本进行了纳米孔（Nanopore）全基因组测序，以进一步探究风险单倍型。