Gut microbiota dependent and independent impacts of dietary pulses on pre- and postprandial metabolism and inflammation in overweight/obese humans

The study goal was to determine gut microbiome dependent and independent impacts of pulse consumption on metabolic resilience and metabolic risk profiles for type 2 diabetes (T2D) and cardiovascular disease (CVD) risk. Specifically, pulse crop consumption has unrealized potential to fundamentally alter how the body responds to disease promoting metabolic stresses of postprandial triglyceride and inflammation responses. Specific study objectives were to (1) Determine the impact of 12 weeks of green lentil consumption on postprandial triglyceride (TG) and inflammation responses to a high-fat meal challenge. (2) Determine the extent to which the gut microbiome and changes in the gut microbiome induced by pulse consumption influence health impacts (3) Measure metabolomic profiles to elucidate underlying mechanisms linking pulse consumption to improved health.

本研究的首要目标为明确食用豆类摄入对代谢弹性（metabolic resilience）以及2型糖尿病（T2D）、心血管疾病（CVD）相关代谢风险谱的肠道微生物组（gut microbiome）依赖性与非依赖性影响。具体而言，食用豆类作物具备尚未被充分发掘的潜力，可从根本上重塑机体对促疾病性代谢应激的应答模式，涵盖餐后甘油三酯与炎症应答两类指标。本研究的具体研究目标如下：（1）明确12周绿扁豆摄入对高脂膳食负荷下餐后甘油三酯（TG）与炎症应答的影响；（2）明确肠道微生物组以及食用豆类诱导的肠道微生物组变化对健康效应的影响程度；（3）测定代谢组学谱，以阐明食用豆类摄入与健康改善之间的潜在关联机制。