Additional file 4: Table S3. of Next generation sequencing of triple negative breast cancer to find predictors for chemotherapy response

List of all mutations. This file shows all mutations passing thresholds as explained in “Methods”. The column “confirmed” shows mutations that have been confirmed by either Sanger Sequencing or deep whole exome sequencing in another research project (unpublished data). The column “included in analysis” shows the mutations that passed our threshold for putative driver mutations, based on effect, SIFT, polyphen scores and COSMIC (see “Methods”). The column “dubious” shows the mutations that might be dubious based on gene length, expression or replication time [20]. (XLSX 64 kb)

全部突变位点列表。本文件收录了所有符合《方法》章节所述筛选阈值的突变位点。其中，"确认"列标注了经另一项未发表研究中的桑格测序（Sanger Sequencing）或深度全外显子组测序（deep whole exome sequencing）验证的突变位点；"纳入分析"列标注了基于突变效应、SIFT评分、Polyphen评分以及COSMIC数据库（详见《方法》章节），通过潜在驱动突变（putative driver mutations）筛选阈值的突变位点；"存疑"列标注了基于基因长度、基因表达水平或复制时间[20]判定为疑似存在问题的突变位点。（XLSX格式，64 KB）