Influence of polidocanol ultrasound-guided foam sclerotherapy on quality of life in lower extremity chronic venous disease: initial results

Abstract Chronic Venous Insufficiency (CVI) is not only detrimental to patients’ Quality of Life (QoL) but also places a considerable burden on public health resources. Ultrasound guided foam sclerotherapy (USFS) is a good treatment option, but its effect on patients’ QOL is still unclear. This article presents the results from the first 27 patients in a prospective, longitudinal, non-controlled study for evaluation of the clinical and QOL impact of USFS treatment for CEAP C4 to C6 grade CVI with contraindications for open surgery. Clinical symptoms were measured with the Venous Clinical Severity Score (VCSS) and QOL by the Assessment of Burden Chronic Disease - Venous questionnaire (ABC-V). We observed 22.2% reductions in VCSS (p<0.001) in the first week after the procedure, and a 37.8% reduction in ABC-V scores (p=0.03) over the first 3 months.

摘要：慢性静脉功能不全（Chronic Venous Insufficiency，CVI）不仅严重损害患者的生活质量（Quality of Life，QoL），还给公共卫生资源带来沉重负担。超声引导泡沫硬化疗法（Ultrasound guided foam sclerotherapy，USFS）是此类患者的优选治疗方案，但该疗法对患者生活质量的影响尚不明确。本文报告了一项前瞻性、纵向、非对照研究的前27例患者数据，该研究旨在评估超声引导泡沫硬化疗法对存在开放手术禁忌证的CEAP分级C4至C6级慢性静脉功能不全患者的临床疗效及生活质量影响。临床症状采用静脉临床严重程度评分（Venous Clinical Severity Score，VCSS）进行评估，生活质量则采用慢性疾病负担评估-静脉问卷（Assessment of Burden Chronic Disease - Venous questionnaire，ABC-V）进行测评。结果显示，术后第一周患者的VCSS评分降低22.2%（p<0.001）；术后前3个月内，ABC-V评分降低37.8%（p=0.03）。