Data_Sheet_1_Analyzing the bibliometrics of brain-gut axis and Parkinson’s disease.docx

BackgroundParkinson’s disease (PD), characterized by the loss of dopaminergic neurons, is a progressive neurodegenerative disorder. Recent research has revealed a significant connection between gut microbiota and PD. To gain insight into research interests, disciplinary contexts, and potential future directions, a comprehensive bibliometric analysis was conducted on the brain-gut axis and PD literature published between 2014 and 2023.
MethodsRelevant literature records were gathered from the Web of Science Core Collection on August 11, 2023. The data were then analyzed by Biblioshiny R packages and VOSviewer (version 1.6.19).
ResultsThe dataset revealed an upward trend in annual scientific publications on the brain-gut axis and PD, with an annual growth rate of 50.24%. China, the United States, and Italy were the top three most productive countries/regions. The journal “International Journal Of Molecular Sciences” published the most articles, while “Movement Disorders” received the highest number of citations. Professor Keshavarzian A emerged as the most prolific author, while Professor Scheperjans F held the highest h-index. Keyword analysis highlighted “alpha-synuclein” as the most frequent term, with “mouse model,” “inflammation,” and “risk” as emerging research topics. Additionally, “central nervous system” and “intestinal bacterial overgrowth” attracted increasing attention.
ConclusionThis study examined current trends and hotspots in the bibliometric landscape of the brain-gut axis and PD research. Future research directions should explore the functional and metabolic activities of gut microbiota. Additionally, transitioning from observational to interventional study designs offers the potential for personalized interventions and disease prediction. These findings can guide researchers in navigating the latest developments and shaping the future directions of this field.

背景：帕金森病（Parkinson’s disease, PD）以多巴胺能神经元丢失为特征，是一种进行性神经退行性疾病。近年来的研究揭示了肠道菌群（gut microbiota）与帕金森病之间存在显著关联。为深入探究该领域的研究关注点、学科语境及潜在未来方向，本研究对2014年至2023年间发表的有关脑-肠轴（brain-gut axis）与帕金森病的文献开展了全面的文献计量分析（bibliometric analysis）。
方法：本研究于2023年8月11日从Web of Science核心合集（Web of Science Core Collection）中检索获取相关文献记录，并采用Biblioshiny R包（Biblioshiny R packages）与VOSviewer（版本1.6.19）对数据进行分析。
结果：本数据集显示，脑-肠轴与帕金森病相关的年度学术发文量呈上升趋势，年增长率达50.24%。中国、美国和意大利是发文量最高的三个国家/地区。《国际分子科学杂志》（International Journal Of Molecular Sciences）的发文量最多，而《运动障碍》（Movement Disorders）的总被引频次最高。Keshavarzian A教授为最高产的作者，Scheperjans F教授的h指数（h-index）最高。关键词分析结果显示，α-突触核蛋白（alpha-synuclein）是出现频次最高的术语，小鼠模型（mouse model）、炎症（inflammation）与风险（risk）为新兴研究主题。此外，中枢神经系统（central nervous system）与肠道细菌过度增殖（intestinal bacterial overgrowth）受到的关注度日益提升。
结论：本研究梳理了脑-肠轴与帕金森病研究领域的文献计量现状与研究热点。未来的研究方向可聚焦于肠道菌群的功能与代谢活动，同时从观察性研究设计向干预性研究设计转型，有望实现个性化干预与疾病预测。本研究结果可为科研人员把握该领域最新进展、明确未来研究方向提供参考。