Scientific projects of the IBS synchrotron group

We study the structures of a broad diversity of macromolecules from fluorescent to metabolic proteins. One of our primary focus is on solving the 3D structures of enzymes within the MEP pathway, as they represent promising drug targets. Additionally, we are engaged in characterizing new fluorescent proteins derived for instance from bacteriophytochrome. Our research activities also include the development of instrumentation and methodologies, spanning from crystallization to room temperature data collection. We strive to enhance crystal quality for both X-ray and neutron diffraction. Furthermore, we conduct high-throughput screening (HTS) of chemical libraries to identify active ligands targeting proteins with pharmaceutical relevance.

本团队针对涵盖荧光蛋白、代谢蛋白在内的多样化大分子开展结构研究。本研究的核心方向之一为解析MEP途径（MEP pathway）中酶的三维结构，因其为极具潜力的药物作用靶点。此外，团队还致力于表征例如源自细菌光敏色素的新型荧光蛋白。本研究的科研活动还涵盖仪器设备与实验方法的开发，研究范围覆盖从蛋白质结晶到室温数据采集的全流程。我们致力于提升X射线衍射与中子衍射所用晶体的质量。进一步而言，我们还针对化学文库开展高通量筛选（high-throughput screening, HTS），以识别针对具有药用价值的蛋白的活性配体。