Demyelinating peripheral polyradiculoneuropathy associated with the use of carbamazepine in dog: case report

ABSTRACT Different drugs are used in the treatment of epilepsy and, like other drugs, may induce the occurrence of adverse effects, some of them so severe that the drug must be discontinued and replaced. Carbamazepine may lead to changes in the cardiovascular, respiratory, and neurological systems, and cases of induction of myasthenia gravis as a neuromuscular disorder have been described in the literature. This paper reports the case of a dog that developed demyelinating polyradiculoneuropathy, probably triggered by carbamazepine. The patient presented tetraplegia, absence of spinal reflexes in the four limbs, cervical weakness, decreased bilateral eyelid reflex and respiratory effort. Electroneuromyography showed signs of demyelination. This, therefore, is the first report of association between carbamazepine and demyelinating polyradiculoneuropathy in dogs.

摘要：癫痫的临床治疗需使用多种药物，与其他药物类似，此类药物可能诱发不良反应，部分不良反应程度严重，需停用原药并更换替代药物。卡马西平（Carbamazepine）可对心血管、呼吸及神经系统造成不良影响，现有文献中已有其诱发重症肌无力（myasthenia gravis）这类神经肌肉疾病的病例报道。本研究报道一例由卡马西平可能诱发脱髓鞘性多发性神经根神经病（demyelinating polyradiculoneuropathy）的犬类病例。该患犬表现为四肢瘫痪、四肢脊髓反射消失、颈部无力、双侧眼睑反射减弱以及呼吸动力下降；神经肌电图检查可见脱髓鞘相关体征。因此，本研究为首次报道犬类卡马西平与脱髓鞘性多发性神经根神经病之间的关联病例。