Associations of <i>MTNR1B</i> SNPs rs10830963 and rs3781638 with anthropometrics, insulin sensitivity, and insulin secretion (N = 1578).

Data represent means±SD. For statistical analysis, data were log-transformed and adjusted. BMI, body fat, and waist circumference were adjusted for gender and age. Plasma glucose levels, indices of insulin sensitivity, and the disposition index were adjusted for gender, age, and BMI. Other indices of insulin secretion were adjusted for gender, age, BMI, and ISI (OGTT). p1–p-value after adjustment as described; p2–p-value after additional adjustment for family history of diabetes. Significance levels withstanding Bonferroni correction for multiple comparisons are marked in bold letters. AUC–area under the curve; HOMA-IR–homeostasis model assessment of insulin resistance; ISI–insulin sensitivity index; SNP–single nucleotide polymorphism. *subgroup (N = 513).数据以均值±标准差（standard deviation, SD）表示。本研究先对数据进行对数转换并校正后开展统计学分析：体重指数（Body Mass Index, BMI）、体脂及腰围按性别与年龄进行校正；血浆葡萄糖水平、胰岛素敏感性指标及处置指数（disposition index）按性别、年龄及BMI进行校正；其余胰岛素分泌相关指标按性别、年龄、BMI及胰岛素敏感性指数（insulin sensitivity index, ISI，口服葡萄糖耐量试验（Oral Glucose Tolerance Test, OGTT））进行校正。p1为按上述方案校正后的P值；p2为额外加入糖尿病家族史因素校正后的P值。经Bonferroni多重比较校正后仍具有统计学显著性的检验水准以粗体标注。缩写说明如下：曲线下面积（area under the curve, AUC）、胰岛素抵抗稳态模型评估（homeostasis model assessment of insulin resistance, HOMA-IR）、胰岛素敏感性指数（insulin sensitivity index, ISI）、单核苷酸多态性（single nucleotide polymorphism, SNP）。*亚组（样本量N=513）。