Potent and selective PTDSS1 inhibitor targeting collateral lethality against cancer with PTDSS2 deletion [xeno_RNA-seq]. Potent and selective PTDSS1 inhibitor targeting collateral lethality against cancer with PTDSS2 deletion [xeno_RNA-seq]

To decipher the underlying mechanism governing selective growth arrest in PTDSS1-inhibited PTDSS2-depleted cancer cells, we analyzed the transcriptomic changes brought about by comparing vehecle treated and DS55980254 treated PTDSS2-KO HCT116 s.c. tumors. Overall design: Comparative gene expression profiling analysis of RNA-seq data for cancer xenograft models

为解析PTDSS1抑制且PTDSS2敲除的癌细胞中选择性生长停滞的潜在调控机制，本研究通过对比赋形剂处理与DS55980254处理的PTDSS2-KO HCT116细胞皮下移植瘤，分析了二者的转录组变化。实验整体设计：针对癌症异种移植模型的RNA测序（RNA-seq）数据开展比较基因表达谱分析。