ADAD2 facilitates piRNA biogenesis and spermiogenesis in mice

Adenosine Deaminase Domain Containing 2 (ADAD2) is a testis-specific protein composed of a double-stranded RNA binding domain and a non-catalytic adenosine deaminase domain. A recent study showed that ADAD2 is indispensable for the male reproduction in mice. However, its detailed function remains elusive. The aims of this study are to investigate the cause of male sterility in Adad2 knockout mice and to understand the molecular function of ADAD2. RNA-seq analyses were carried out to analyze the changes in the transcriptome and piRNA population of Adad2 mutant testes. RNA-seq of testis from Adad2-knockout mouse