Transcriptomic profile of lungs of hamsters infected with SARS-CoV-2. Mesocricetus auratus

We investigated the therapeutic effect of oral antiviral ensitrelvir and anti-inflammatory corticosteroid methylprednisolone in hamsters infected SARS-CoV-2. The infected hamsters were treated with (1) vehicle containing no drug, (2) ensitrelvir, (3) methylprednisolone alone, or (4) ensitrelvir combined with methylprednisolone. The dataset contains the results of mRNA-seq of lungs of the hamsters at 4 days post infection. This project revealed the effect of drug treatments on host inflammatory responses to SARS-CoV-2 infection.

本研究探究了口服抗病毒药物恩司特韦（ensitrelvir）与抗炎糖皮质激素甲泼尼龙（methylprednisolone）在感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的仓鼠中的治疗效果。感染病毒的仓鼠被分为四组接受给药处理：(1) 不含任何药物的赋形剂对照组，(2) 恩司特韦单药组，(3) 甲泼尼龙单药组，(4) 恩司特韦与甲泼尼龙联合给药组。本数据集包含感染后第4天时仓鼠肺部组织的mRNA测序（mRNA-seq）结果。本研究阐明了药物治疗方案对宿主针对SARS-CoV-2感染的炎症应答的调控效应。