Supplementary Material for: Age-Dependent Predictors for Recurrent Stroke: The Paradoxical Role of Triglycerides

Background: Although long-term predictors of mortality and vascular events after ischemic stroke are well defined, the age-dependent differences in predicting outcomes are unknown, particularly for lipid parameters. Methods: We assessed recurrent stroke and other vascular events in patients with first-ever ischemic strokes who were registered in a prospectively collected hospital-based stroke registry. Patients were classified into a middle-age group (40–64 years old) and an old-age group (65 years and older). Results: A total of 551 patients comprising 235 middle-age and 316 old-age subjects were investigated. At the mean follow-up of 26.4 months, 49 (8.9%) patients had experienced recurrent stroke. Outcome events in the middle-age group (3.8%) were less frequent than in the old-age group (12.7%). The effects of vascular risk factors were different across age groups. In particular, the hazard ratio direction for triglycerides was significantly different between age groups for recurrent stroke or composite outcomes. Conclusions: Incidence and predictors of stroke and other vascular events following ischemic stroke are age-dependent. Differential effects of triglycerides on long-term outcomes following ischemic stroke were found to be hazardous at middle age but turned out to be non-significant at old age.背景：尽管缺血性脑卒中（ischemic stroke）后死亡与血管事件的长期预测因素已得到明确界定，但目前尚不清楚预后预测中存在的年龄依赖性差异，尤其是针对血脂参数（lipid parameters）。 方法：我们对前瞻性收集的医院脑卒中登记数据库中登记在册的首次缺血性脑卒中患者的复发脑卒中及其他血管事件进行了评估。将患者分为中年组（40~64岁）与老年组（65岁及以上）。 结果：本研究共纳入551例患者，其中中年组235例，老年组316例。平均随访时长为26.4个月，期间共有49例（8.9%）患者出现复发脑卒中。中年组的预后事件发生率（3.8%）低于老年组（12.7%）。不同年龄组的血管危险因素影响存在差异。具体而言，在复发脑卒中或复合终点事件中，甘油三酯的风险比（hazard ratio, HR）方向在年龄组间存在显著不同。 结论：缺血性脑卒中后脑卒中及其他血管事件的发生率与预测因素存在年龄依赖性。研究发现，甘油三酯对缺血性脑卒中后长期预后的影响存在差异：在中年人群中表现为有害作用，而在老年人群中则无统计学显著性意义。