Oral vaccine strain. Salmonella enterica subsp. enterica serovar Typhi str. Ty21a

Salmonella enterica subsp. enterica serovar Typhi. This serovar is a human-specific organism that causes the life-threatening illness Typhoid fever which is acquired by coming into contact with contaminated food or water. Annually, 17 million people are infected, with 600,000 fatalities, mostly in developing countries. It contains multiple fimbrial operons that may be used to create extracellular appendages for attachment and entry into host intestinal epithelial cells. Salmonella enterica subsp. enterica serovar Typhi str. Ty2. Salmonella enterica subspecies enterica serovar Typhi str. Ty2 is an oral vaccine strain. This strain will be used for comparative analysis.

伤寒沙门氏菌（Salmonella enterica subsp. enterica serovar Typhi）为人类专属病原体，可引发致死性疾病伤寒，人类可通过接触受污染的食物或水源感染该病菌。每年约有1700万人受到感染，其中60万人因此死亡，病例大多分布于发展中国家。该菌携带有多个菌毛操纵子（fimbrial operons），这些操纵子可用于合成细胞外附属结构，以介导其黏附并侵入宿主肠上皮细胞。伤寒沙门氏菌Ty2菌株（Salmonella enterica subsp. enterica serovar Typhi str. Ty2）。该菌株为口服疫苗株，将被用于比较分析。